Chime also has a pop-up menu that allows a visitor to a website to execute a subset of the Rasmol commands. These commands are either executed when a plug-in is loaded or can be activated by a visitor to the site using buttons and other control elements. For Chime the commands are coded into the web page by its author. For Rasmol the commands are entered from a command line with a subset of the commands available from the menu bar. Both Rasmol and Chime use the same command library for loading and manipulating molecular modes. Chime was developed at Molecular Design Limited (MDL) and took the Rasmol code and modified it so that it could be used as a web browser plug-in to display three-dimensional, interactive molecular models from webpages. There are versions available for Windows, Unix and older versions of MacOS (prior to MacOS X). Rasmol was written in the early 1990's by Roger Sayle as a standalone application and was distributed free of charge. Over past couple of years Jmol has emerged as a viable replacement for two long-standing tools used for visualizing macromolecules on personal computers, Rasmol and Chime. Jmol is a Java-based molecular modeling application that can be used either in a stand-alone mode, or as an embedded object in webpages. These are show as spacefilling models and colored to atom type. Bound to the enzyme is fructose-1,6-bisphosphate, which is an allosteric effector for the enzyme, and phlosphoglycolic acid, which is a substrate analogue and inhibitor for the enzyme. The protein is modeled as a cartoon and colored to highlight the secondary structure of the protein. The pages are best viewed using a display that is at least 1000 pixels wide.Figure: Shown above is a Jmol model for the enzyme pyruvate kinase, which catalyzes the last reaction in the glycolytic pathway. If they do not appear check that JavaScript is enabled in your browser and try again. If your system is compatible, you should see two of them in windows to the right. ChemInteractive should run on just about any computer, and on tablets and smart phones, but the applets may be slow, and difficult to use on smart phones. Firefox works very well, but there are some issues using Chrome, which we are trying to resolve. The apps should run in just about any modern web browser, but not in Internet Exporer 8 or earlier versions. These sophisticated tools are freely available through the talent and generosity of the developers credited at the bottom of the page. The principal applets are "JSME", a molecular editor that allows easy drawing of chemical structures, "JSmol", a 3D viewer for chemical structures, and "ChemDoodle Web Components", a set of apps for drawing and visualising structures, mechanisms and spectra. The interactive functionality of ChemInteractive is made possible by the use of embedded applications for drawing and displaying chemical structures. Reusch has also compiled an extensive set of problems in organic chemistry. Many of these links are to sections of the Virtual Textbook of Organic Chemistry, the excellent, freely available, online textbook produced by Professor William Reusch of the Department of Chemistry, Michigan State University. Most provide links to helpful resources that users can consult to help them learn the material.Most allow the users to choose the level of difficulty of the problems, so that they can choose problems appropriate to their background knowledge and their learning goals.For example, if an answer is not correct, the feedback will provide information that will help the learner to identify, and correct, the error. Most provide detailed feedback to the user.This is valuable for learning how to draw molecular structures and reaction mechanisms. Most require the user to draw, or interact with, chemical structures. It is targeted at students learning Organic Chemistry in the early years of College or University programmes.Ĭheck the menu at the top to see what topics are available.įor each topic ChemInteractive provides problem activities to help students test, and improve, their learning. ChemInteractive is a free site designed to promote active learning of Chemistry.
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